Every day, millions of Americans take prescription drugs and over-the-counter medicines to treat a variety of ailments ranging from incontinence, to depression, to allergies and more. New research, however, shows that previously unknown risks associated with certain associated drugs may be contributing to elevated rates of dementia in aging adults.
Today, dementia and Alzheimer’s Disease are at near epidemic levels. They currently affect over 50 million people worldwide, and about 10 million more people are diagnosed every year.
Millions of Americans and their families have also been painfully impacted by the devastating effects of dementia. These can include, but not be limited to, severe memory loss and deteriorating judgement, decision making, and behavioral functions. Alzheimer’s Disease alone is the sixth leading cause of death in the United States, and there is no known cure.
Several groundbreaking studies in recent years have shed light on the issue by establishing a compelling link to a class of drugs known as “anticholinergics.” These include highly technical drug names like amitriptyline, dosulepin, and paroxetine, for example, and others like oxybutynin, solifenacin, and tolterodine.
In plain English, these are are used to treat depression and the loss of bladder control.
Other conditions regularly treated with anticholinergic drugs include asthma, chronic obstructive pulmonary disease and Parkinson’s disease. Some studies include diphenhydramine, an anticholinergic ingredient in many commonly used antihistamines. Common medicines containing diphenhydramine include Benadryl, Motrin, Midol and Robitussin — although it’s important to note that these medicines have not been shown to cause dementia, only that diphenhydramine has anticholinergic effects. Anticholinergics work by blocking a chemical messenger, or neurotransmitter, called acetylcholine that carries brain signals for controlling muscles.
A new British study found that long-term use of certain anticholinergics is significantly linked to dementia, especially those used to treat depression and Parkinson’s disease. But unlike other studies, it did not find a connection between antihistamines and dementia.
Shockingly, in some cases, a link was established for study participants who took anticholinergic drugs 15-20 years before being diagnosed with dementia. Scientists concluded that such cases reduced the possibility of mere correlation between these drugs and dementia.
While there’s much research to be done, every new study advises both physicians and patients to be vigilant about the use of anticholinergic drugs. We know just how hard it can be when a loved one faces a diagnosis like this. Do not wait to contact our office on this issue or any elder care issue you or a family member may be facing.